Insulin antibodies in response to human insulin therapy in infants. 393
نویسندگان
چکیده
منابع مشابه
Insulin-binding antibodies in relation to insulin therapy.
Methods for detecting insulin binding or transporting antibodies are described, involving the use of radioactively labelled insulin (insulin (131)I). These antibodies are detected in a high proportion of patients receiving insulin, particularly those requiring large doses. The protein fractions concerned appear to be the beta and gamma globulins. The significance of the phenomenon is discussed.
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Background and Aim: Diabetes is a common disorder worldwide, and exhaustive efforts have been made to cure this disease. Gene therapy has considered as a potential curative method that has more stability in comparison with the other pharmaceutical methods. However, the application of gene therapy as a definitive treatment demands further investigation. This study aim is to prepare a suitable hi...
متن کاملDesigning an Engineered Construct Gene Sensitive to Carbohydrate In-vitro and Candidate for Human Insulin Gene Therapy In-vivo
Background and Aim: Diabetes is a common disorder worldwide, and exhaustive efforts have been made to cure this disease. Gene therapy has considered as a potential curative method that has more stability in comparison with the other pharmaceutical methods. However, the application of gene therapy as a definitive treatment demands further investigation. This study aim is to prepare a suitable hi...
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A relationship between insulin resistance (IR) and insulin antibodies (IAs) was first described in the 1950s and was thought to be due to the use of nonhuman insulins (1). Since the introduction of human insulin, the presence of IAs and consequent IR was felt to be clinically insignificant (2). The presence of high levels of IAs, associated with random hypoglycemia in insulin-naive patients, is...
متن کاملInsulin Response in Relation to Insulin Sensitivity
OBJECTIVE The purpose of this study was to characterize differences in the acute insulin response to glucose (AIR(g)) relative to insulin sensitivity (S(I)) in black and white premenopausal normoglycemic South African women matched for body fatness. RESEARCH DESIGN AND METHODS Cross-sectional analysis including 57 black and white South African women matched for BMI, S(I), AIR(g), and the disp...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1997
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-199704001-00413